Everton vs Lyon 20/10/2017
Both teams will meet for the first time, but for Everton, they will need to take all three points if they want to keep their qualification hopes alive. The big-spending Toffees have yet to get going this season and Ronald Koeman is under serious pressure to turn the corner.
Everton have not conceded in their previous matches against French sides, drawing 0-0 away and winning 3-0 at home against Lille in the 2014/15 Europa League group stage.
Lyon have a losing record against English teams, although one of their three wins came in their last trip, a 2-1 win at Anfield. Defeat for either side at Goodison Park could well close the lid on their European adventure. Lyon are third in the group on two points, while Everton are a spot and a point behind.